C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/264
C07D 401/12 (2006.01) C07D 237/04 (2006.01) C07D 237/14 (2006.01) C07D 237/20 (2006.01) C07D 401/04 (2006.01) C07D 403/12 (2006.01) C07D 409/04 (2006.01) C07D 413/12 (2006.01) C07D 451/02 (2006.01) C07D 451/04 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2009501
ABSTRACT OF DISCLOSURE The present invention relates to pyridazine derivatives of formula : Image (I) in which - Ar is a group Image a pyridyl or a thienyl ; - R1 and R2 independently are each hydrogen, a halogen atom, a hydroxyl group, a trifluoromethyl group, a C1-C4 alkoxy group or a C1-C4 alkyl group ; - R3 is a C1-C4 alkyl-group or a phenyl ; and R4 is : - a group Image in which Alk is C1-C6 alkylene group, R5 is hydrogen or a C1-C6 alkyl group and R6 is a C1-C4 alkyl group, a benzyl or a C3-C7 cycloalkyl, or R5 and R6 form, with the nitrogen atom to which they are bonded, a heterocycle selected from morpholine, thiomorpholine, pyrrolidine, N-methylpiperazine and piperidine which is unsubstituted or substituted by one more methyl groups, by a hydroxyl, by a phenyl or by a benzyl ; - a group Image in which Alk' is a C1-C3 alkylene group and R7 is a C1-C4 alkyl group ; or - a group Image in which Alk' is as defined above and substitutes the pyridine in the 2-, 3- or 4-position, with the limitation that R1 and R2 are not simultaneously hydrogen when R4 is group (CH2)2NR5R6, and its salts with mineral or organic acids.
Bourguignon Jean-Jacques
Brodin Roger
Olliero Dominique
Wermuth Camille Georges
Worms Paul
Sanofi
Sim & Mcburney
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