C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/42 (2006.01) A61K 31/695 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2046730
ABSTRACT OF THE DISCLOSURE A compound of the formula (I): Image (I) wherein X1 and x2 do not exist or represent oxygen atom; A represents OH or acyloxy group having 1 to 4 carbon atoms; B represents hydrogen atom; A and B together represent a bond; and R2 represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, or R1 and R2 together represent 1,2-ethylene , 1,3- propylene, 1,4-butylene or 1,5-pentylene, and these alkylene groups may be substituted by alkyl group having 1 to 4 carbon atoms; R3 represents amido group of the formula: Image wherein n, R4, R5, R6, R7, R8, R9, R10 and R11 represent specific groups, and the pharmacological acceptable salts of the compounds which can form salts have strong activity for lowering blood pressure, and process therefor and pharmaceutical use of the compounds.
Kamikawaji Yoshimasa
Masuda Yukinori
Matsumoto Hiroo
Ohdoi Keisuke
Ohrai Kazuhiko
Gowling Lafleur Henderson Llp
Nissan Chemical Industries Ltd.
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