Pyranone derivatives useful for treating cancer

Details Pyranone derivatives useful for treating cancer Pyranone derivatives useful for treating cancer

C - Chemistry, Metallurgy

07

D

C07D 309/38 (2006.01) A61K 31/366 (2006.01) A61P 35/00 (2006.01) C07C 47/273 (2006.01)

Patent

CA 2553318

The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and R¿1? and R¿2? is independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or R¿1? and R¿2? form together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer are also disclosed.

La présente invention concerne des dérivés de pyranone, de formule générale (I), dans laquelle X représente le chlore, le brome ou l'iode et R1 et R2 représentent chacun indépendamment l'un de l'autre un atome d'hydrogène, un groupe alkyle, cycloalkyle ou alkylène, linéaire ou ramifié, contenant de 1 à 20 atomes de carbone, éventuellement substitué par un groupe hydroxyle, amino, éther ou halogène, ou R1 et R2 forment ensemble un cycle de 5, 6, 7 ou 8 membres, ledit cycle étant éventuellement substitué par un groupe hydroxyle, amino, éther ou halogène, y compris ses isomères, ses énantiomères, ses diastéréoisomères, et leurs mélanges. La présente invention concerne également leur procédé de préparation et leur application thérapeutique, notamment pour le traitement du cancer.

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