C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) C07D 213/74 (2006.01) C07D 241/20 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2530389
The present invention relates to a compound and a group of compounds of formula (I) and (II) with the definitions of R1 -R6 according to claim 1 which are inhibitors of Rho kinase (ROK, ROCK). In addition, the invention relates to methods of treatment and use of the compounds in the manufacture of a medicament for application to a number of therapeutic indications including cardiovascular disease (coronary vasospasm, hypertensive disease, arteriosclerosis), stroke, cancer, erectile dysfunction, asthma, osteoporosis, glaucoma and AIDS. The compounds can be used in screening programmes against protein kinases. The invention also provides methods for making compounds and libraries that include these compounds.
La présente invention concerne un composé et un groupe de composés inhibiteurs de la Rho kinase (ROK, ROCK). Cette invention concerne également des méthodes de traitement et l'utilisation de ces composés dans la production d'un médicament présentant un certain nombre d'indications thérapeutiques parmi lesquelles figurent la maladie cardiovasculaire (vasospasme coronaire, affection hypertensive, artériosclérose), l'accident vasculaire cérébral, le cancer, la dysérection, l'asthme, l'ostéoporose, le glaucome et le SIDA. Ces composés peuvent être utilisés dans des programmes de criblage contre des protéine kinases. Ladite invention concerne également des procédés de production desdits composés ainsi que des bibliothèques comportant ces composés.
Birault Veronique
Harris John C.
Biofocus Discovery Limited
Galapagos Nv
Gowling Lafleur Henderson Llp
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