Pyrazine compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 241/26 (2006.01) A61K 31/4965 (2006.01)

Patent

CA 2341543

A compound of formula (I) wherein R1 is phenyl substituted by one or more halogen atoms; R2 is -NH2; R3 is -NH2 or hydrogen; R4 is -CXNRaRb, -CXNH- (CH2)y-NRaRb; wherein X is = O or = S; y is an integer zero, 1 or 2; Ra and Rb, which may be the same or different, are selected from hydrogen and C1-4 alkyl or together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocycle containing one or two nitrogen heteroatoms, which heterocycle can be further substituted with one or more C1- 4 alkyl groups; and pharmaceutically acceptable derivatives thereof.

L'invention concerne un composé de formule (I) : Où R?1¿ représente un phényle substitué par au moins un atome halogène; R?2¿ représente -H¿2?; R?3¿ représente -H¿2? ou l'hydrogène; R?4¿ représente -XNR?a¿R?b¿, -CXNH-(CH¿2?)¿y?-NR?a¿R?b¿, sachant que X représente =O ou =S; y vaut 0,1 ou 2; R?a¿ et R?b¿, qui peuvent être identiques ou différents, représentent de l'hydrogène ou C¿1-4? alkyle, ou ensemble avec l'atome d'azote auquel ils sont attachés,forment un hétérocycle saturé à 5 ou 6 éléments contenant un ou deux hétéroatomes d'azote, lequel hétérocycle peut de plus être substitué par au moins un groupes C¿1-4? alkyle; L'invention concerne aussi des dérivés pharmaceutiquement compatibles de ce composé.

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