Pyrazine compounds, their use and methods of preparation

Details Pyrazine compounds, their use and methods of preparation Pyrazine compounds, their use and methods of preparation

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/4418 (2006.01) A61K 31/4427 (2006.01) A61K 31/444 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) C07D 241/20 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2660560

The invention provides compounds according to formula (I) their use and methods for preparation wherein A, X, Y, R1, R2 and R3 are defined herein. The compounds of the invention inhibit specific serine/threonine kinases involved in inflammatory processes and aberrant cell proliferation, and are thus useful for treating associated diseases and pathological conditions such as Pim kinase-mediated diseases and pathological conditions involving inflammation, including Chron's disease, inflammatory bowel disease, rheumatoid arthritis, and chronic inflammatory disease, or aberrant cell proliferation including various cancers.

L'invention concerne des composés représentés par la formule (I), leur utilisation et des procédés de préparation, A, X, Y, R1, R2 et R3 étant tels que définis ici. Les composés de l'invention inhibent des kinases de sérine/thréonine spécifiques impliquées dans des processus inflammatoires et des proliférations cellulaires aberrantes, et sont donc utiles pour traiter des maladies et des conditions pathologiques associées, telles que les maladies favorisées par Pim kinase, ainsi que des conditions pathologiques impliquant une inflammation, dont la maladie de Crohn, la maladie intestinale inflammatoire, l'arthrite rhumatoïde et la maladie inflammatoire chronique, ou une prolifération cellulaire aberrante, dont divers cancers.

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