C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/246
C07D 403/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 1293251
ABSTRACT OF THE DISCLOSURE The present invention relates to derivatives of pyrazine represented by general formula Image wherein R represents hydrogen atom or Image , wherein R1 and R2 which may be the same or different, represent hydrogen atom, straight or branched-chain lower alkyl group or cycloalkyl group having 3 to 6 carbon atoms, phenyl group, which may be substituted with halogen, lower alkyl group or lower alkoxyl group, or 5 to 7 membered-ring together with the neighborous nitrogen atom, which may have oxygen atom, nitrogen atom or sulfur atom as ring-member and may be substituted with substituent, and pharamacuetically-acceptable salts thereof. The compounds of the invention are useful for treatment of bronchial asthma, allergic gastroenteric trouble, hay fever urticaria, allergic rhinitis and allergic conjunctivitis. .
525801
Itoh Yasuo
Kato Hideo
Koshinaka Eiichi
Mitani Kazuya
Ogawa Nobuo
Hokuriku Pharmaceutical Co. Ltd.
Itoh Yasuo
Johnson Douglas S. Q.c.
Kato Hideo
Koshinaka Eiichi
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