Pyrazine derivatives and their use as protein kinase inhibitors

Details Pyrazine derivatives and their use as protein kinase inhibitors Pyrazine derivatives and their use as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 241/20 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61K 31/5415 (2006.01) A61P 17/00 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2713553

The present invention relates to compounds of the general formula (I) wherein R1, R2 and R3 are as defined herein, which can act as inhibitors of protein kinases, specially the Fms-like tyrosine kinase 3 (FLT3). The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of hematological malignancies, such as AML, MLL, T-ALL, B- ALL and CMML, myeloproliferative disorders, other proliferative disorders like cancer, autoimmune disorders and skin disorders like psoriasis and atopic dermatitis.

La présente invention concerne de composés de formule générale (I) dans laquelle R1, R2 et R3 sont tels que définis dans ce document, pouvant agir en tant qu'inhibiteurs de protéine kinases, spécialement la tyrosine kinase 3 de type Fms (FLT3). L'invention a également pour objet l'utilisation des composés en thérapie, des compositions pharmaceutiques renfermant les composés et l'utilisation des composés pour la préparation d'un médicament destiné à la prophylaxie et au traitement d'affections hématologiques malignes, telles que AML, MLL, T-ALL, B-ALL et CMML, des troubles myéloprolifératifs, d'autres troubles prolifératifs comme le cancer, des troubles auto-immuns et des troubles cutanés comme le psoriasis et la dermite atopique.

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