C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2423050
The present invention provides pyrazine derivatives that inhibit tyrosine kinase activity. Certain pyrazine derivatives are selective inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. The present invention also provides pharmaceutical formulations containing the pyrazine derivatives and methods of use of these formulations as anti-tumor agents and to treat solid-tumor cancers, angiogenesis, diabetic retinopathy, rheumatoid arthritis, endometriosis and psoriasis.
L'invention concerne des dérivés de pyrazine inhibant l'activité de tyrosine kinase. Certains de ces dérivés sont des inhibiteurs sélectifs de tyrosine kinase du récepteur de facteur de croissance endothéliale. L'invention concerne également des formulations pharmaceutiques renfermant les dérivés décrits et des procédés relatifs à l'utilisation des formulations considérées comme agents antitumoraux et dans le traitement des cancers à tumeur solide, de l'angiogenèse, de la rétinopathie diabétique, de la polyarthrite rhumatoïde, de l'endométriose et du psoriasis.
Connolly Peter
Deangelis Alan
Emanuel Stuart
Jolliffe Linda
Kuo Gee Hong
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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