C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/04 (2006.01) A61K 31/496 (2006.01) A61K 31/4965 (2006.01) A61K 31/706 (2006.01) A61P 31/12 (2006.01) C07D 241/24 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2398620
Pyrazine derivatives represented by general formula [1]: (see formula 1) wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating viral infections. Further, fluoropyrazine-carboxamide derivatives represented by general formula [2]: (see formula 2) wherein the variables are as defined in the specification, or salts thereof are useful as an intermediate for production of the compounds of general formula [1], and as an intermediate for production of the fluoropyrazine-carboxamide derivatives of which one typical example is 6-fluoro-3-hyroxy-2-pyrazine- carboxamide having an antiviral activity.
La présente invention concerne des dérivés de pyrazine de formule générale (I) ou leurs sels. Ces dérivés présentent d'excellentes activités antivirales et sont utilisés comme remèdes contre l'infection virale. Dans la formule (1), chaque symbole est tel que défini dans le descriptif. Par ailleurs, cette invention concerne des dérivés de fluoropyrazine de formule générale (2) utilisés comme intermédiaires non seulement pour la préparation des composés de formule (1), mais également pour la préparation industrielle de dérivés de fluoropyrazinecarboxamide, tels que 6-fluoro-3-hydroxy-2-pyrazinecarboxamide caractérisés par une activité antivirale. Dans la formule (2), chaque symbole est tel que défini dans le descriptif.
Egawa Hiroyuki
Furuta Yousuke
Hamamoto Shoichi
Sugita Jun
Uehara Sayuri
Marks & Clerk
Toyama Chemical Co. Ltd.
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