Pyrazine derivatives useful as inhibitors of atr kinase

Details Pyrazine derivatives useful as inhibitors of atr kinase Pyrazine derivatives useful as inhibitors of atr kinase

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/497 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2747252

The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; pro-cesses for preparing the compounds of this invention; in-termediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The com-pounds of this invention have formula (I):wherein the variables are as defined herein.

La présente invention porte sur des composés pyrazines utiles en tant qu'inhibiteurs d'ATR protéine kinase. L'invention porte également sur des compositions pharmaceutiquement acceptables comprenant les composés de cette invention ; sur des procédés de traitement de diverses maladies, troubles et états à l'aide des composés de cette invention ; sur des procédés de préparation des composés de cette invention ; sur des intermédiaires pour la préparation des composés de cette invention ; et sur des procédés d'utilisation des composés dans des applications in vitro, telles que l'étude de kinases dans des phénomènes biologiques et pathologiques ; sur l'étude de voies de transduction de signaux intracellulaires à médiation par de telles kinases ; et sur l'évaluation comparative de nouveaux inhibiteurs de kinase. Les composés de cette invention ont la formule (I) : dans laquelle les variables sont telles que définies présentement.

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