C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 1/00 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) C07D 471/14 (2006.01) C07D 487/14 (2006.01)
Patent
CA 2359034
A chemical compound of formula (I) wherein: R1 to R3 are independently selected from hydrogen and lower alkyl; X1 is selected from N and C-R4; X2 is selected from N and C-R5; X3 is selected from N and C-R6; X4 is selected from N and C-R7; R4, R5 and R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkoyl, aryloyl, arylthio, alkylthio, arylthio, alkylsulfoxyl, arylsulfoxyl, alkylsulfonyl, arylsulfonyl, amino, alkylamino, dialkylamino, nitro, cyano, carboalkoxy, carboaryloxy and carboxy; and R6 is selected from hydrogen, halogen, alkyl, aryl, aryloxy, alkylthio, arylthio, alkylsulfoxyl, arylsulfoxyl, alkylsulfonyl, arylsulfonyl, amino, alkylamino, dialkylamino and cyano; with the proviso that R4 to R7 are not all selected as hydrogen, and pharmaceutically acceptable salts and addition compounds and prodrugs thereof; use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes inspidus, and sleep apnea, and especially for the treatment of therapy.
La présente invention concerne un composé chimique de formule (I) où: R¿1? à R¿3? sont indépendamment hydrogène ou les alkyles inférieurs; X¿1? est N ou C-R¿4?; X¿2? est N ou C-R¿5?; X¿3? est N ou C-R¿6?; X¿4? est N ou C-R¿7?; R¿4?, R¿5? et R¿6? sont choisis indépendamment parmi un hydrogène, un halogène, hydroxy, alkyle, aryle, alcoxy, aryloxy, alcoyle, aryloyle, arylthio, alkylsulfoxyle, arylsulfoxyle, alkylsulfonyle, arylsulfonyle, amino, alkylamino, dialkylamino, nitro, cyano, carboalcoxy, carboaryloxy et carboxy; R¿6? est choisi parmi un hydrogène, un halogène, alkyle, aryle, aryloxy, alkylthio, arylthio, alkylsulfoxyl, arylsulfoxyle, alkylsulfonyle, arylsulfonyle, amino, alkylamino, dialkylamino et cyano; à condition que R¿4? à R¿7? ne soient pas tous un hydrogène; et leurs sels et composés d'addition pharmaceutiquement acceptables et leurs prodrogues. L'invention concerne également leur utilisation thérapeutique, notamment pour le traitement des troubles du système nerveux central, des lésions au système nerveux central, des troubles cardio-vasculaires, des troubles gastro-intestinaux, du diabète insipide, et des apnées du sommeil, et particulièrement pour le traitement thérapeutique.
Adams David Reginald
Bentley Jon Mark
Davidson James
Duncton Matthew Alexander James
Porter Richard Hugh Phillip
Kirby Eades Gale Baker
Vernalis Research Limited
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