Pyrazinobenzoxazepines and pyrazinobenzothiazepines

Details Pyrazinobenzoxazepines and pyrazinobenzothiazepines Pyrazinobenzoxazepines and pyrazinobenzothiazepines

C - Chemistry, Metallurgy

07

D

260/238.5

C07D 498/04 (2006.01) C07D 241/24 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1100131

Case 500-5464 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS Abstract of the disclosure Compounds of formula I, Image I wherein R1 is hydrogen, alkyl of 1 to 4 carbon atoms, hydroxyalkyl with a maximum of 4 carbon atoms, which may be acylated by an alkanoyl group of 2 to 18 carbon atoms, alkoxyalkyl - 2 - 500-5464 with a maximum of 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms or a group of formula II, Image II wherein R5 is hydrogen, halogen, alkyl or al- koxy of 1 to 4 carbon atoms, and either i) X is -CH2- and n is 0, 1, 2 or 3 or ii) X is -CO- and n is 1, 2 or 3 or iii) X is -O- and n is 2 or 3 and R2 and R3 are independently hydrogen, halogen, trifluoromethyl or alkyl, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl, each of 1 to 4 carbon atoms and R4 is hydrogen/ alkyl or alkoxy of 1 to 4 carbon atoms, Z is -O- or -S-, with the proviso that, when R3 is trifluoro- methyl, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl, R4 is other than alkoxy, are useful for inducing sleep and treating psychotic dis- turbances and depressions.

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