C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2097465
The novel pyrazinoindoles of the general formula Image I wherein R1 signifies hydrogen, halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy, R2 signifies hydrogen or halogen and R3 signifies hydrogen, lower alkoxy or lower alkylthio, with the proviso that R3 can only signify hydrogen when R1 and R2 are both different from hydrogen, and pharmaceutically acceptable acid addition salts of the compounds of formula I are suitable for the treatment or prophylaxis of central nervous disorders such as depression, bipolar disorders, anxiety, sleep and sexual disorders, psychosis, schizophrenia, migraine and other conditions associated with cephalic pain or other pain types, personality disorders and obsessive-compulsive disorders, social phobia or panic disorders, mental organic disorders, mental disorders in childhood, aggressiveness, age-associated memory impairement and behavioral symptoms, addiction, obesity, bulimia etc.; neural damage resulting from trauma, stroke, neurodegenerative diseases etc.; cardiovascular disorders such as hypertension, thrombosis, stroke etc.; and gastrointestinal disorders such as dysfunction of gastrointestinal tract motility.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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