C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/20 (2006.01) A61K 31/497 (2006.01) A61P 25/00 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2378834
Compounds represented by formula (I) as well as pharmaceutically acceptable salts, esters, N-oxides and hydrates thereof are disclosed. Pharmaceutical compositions and methods of use are also included. The compounds are active against the caspase-3 enzyme, and thus are useful to treat caspase-3 mediated diseases and conditions.
Cette invention se rapporte à des composés représentés par la formule (I), ainsi qu'à des sels, esters, N-oxydes et hydrates de ces composés, acceptables sur le plan pharmaceutique. Des compositions pharmaceutiques et des procédés d'utilisation sont également décrits. Ces composés sont actifs contre l'enzyme caspase-3 et ils sont par conséquent utiles pour traiter les maladies et les états induits par la caspase-3.
Bayly Christopher I.
Colucci John
Giroux Andre
Grimm Erich L.
Han Yongxin
Merck Frosst Canada & Co./merck Frosst Canada & Cie
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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