Pyrazole [3,4-b] pyridine raf inhibitors

Details Pyrazole [3,4-b] pyridine raf inhibitors Pyrazole [3,4-b] pyridine raf inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 13/12 (2006.01) A61P 35/00 (2006.01) C07C 311/08 (2006.01)

Patent

CA 2716952

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

La présente invention concerne des composés de formule I qui sont utiles pour linhibition de kinases Raf. La présente invention concerne des procédés dutilisation de composés de formule I et des stéréo-isomères, tautomères, promédicaments et sels pharmaceutiquement acceptables de ceux-ci, pour le diagnostic, la prévention ou le traitement in vitro, in situ, et in vivo de tels troubles dans des cellules de mammifère, ou des états pathologiques associés.

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