Pyrazole-amides and sulfonamides as sodium channel modulators

Details Pyrazole-amides and sulfonamides as sodium channel modulators Pyrazole-amides and sulfonamides as sodium channel modulators

C - Chemistry, Metallurgy

07

D

C07D 231/24 (2006.01) A61K 31/415 (2006.01) C07D 231/14 (2006.01) C07D 231/20 (2006.01) C07D 231/22 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2525325

Compounds of formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, wherein R1 is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocycle, heterocyclealkyl, heteroaryl, or heteroarylalkyl; R4 is formula (Ia), formula (Ib), formula (Ic), formula (Id), formula (Ie) or formula (If); or formula (II), or a pharmaceutically acceptable salt, amide, ester or prodrug thereof, wherein R14 is formula (III), formula (IV), formula (V), formula (VI), formula (VII), formula (VIII), formula (IX), formula (X), formula (XI), or formula (XII); modulate PN3 in mammals and are useful in treating pain in mammals.

Les composés de la présente invention modulent PN3 chez les mammifères et ils sont utiles dans le traitement de la douleur chez les mammifères.

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