Pyrazole based lxr modulators

Details Pyrazole based lxr modulators Pyrazole based lxr modulators

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/415 (2006.01) C07D 231/12 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2613517

Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

L'invention concerne des composés, représentés notamment par les formules Ia, Ib, Ic ou Id, ainsi que des promédicaments, des isomères et des sels pharmaceutiquement acceptables de ceux-ci, ces composés présentant une utilité comme modulateurs de l'activité des récepteurs X du foie (LXR). Dans les formules susmentionnées, R1, R2, R21, R3 et G sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques contenant ces composés, ainsi que des méthodes d'utilisation desdits composés.

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