Pyrazole carboxamides as inhibitors of...

Details Pyrazole carboxamides as inhibitors of... Pyrazole carboxamides as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 231/16 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) C07D 405/10 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2534221

Pyrazole carboxamides of structural formula (I) are selective inhibitors of the 11.beta.-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.

L'invention concerne des carboxamides de pyrazole représentés par la formule (I) utilisés comme inhibiteurs sélectifs de la dehydrogénase-1 11?-hydroxystéroïde. Ces composés sont utilisés pour traiter les diabètes tels que les diabètes non insulino-dépendents (NIDDM), l'hyperglycémie, l'obésité, la résistance à l'insuline, la dyslipidémie, l'hyperlipidémie, l'hypertension, le syndrome métabolique et d'autres syndromes associés à NIDDM.

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