Pyrazole compositions useful as inhibitors of erk

Details Pyrazole compositions useful as inhibitors of erk Pyrazole compositions useful as inhibitors of erk

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/4155 (2006.01) A61K 31/4439 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 231/10 (2006.01)

Patent

CA 2369076

Described herein are compounds that are useful as protein kinase inhibitors having formula (I) where R1, R2, T and Ht are described in the specification. The compounds are useful for treating disease states inmammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

L'invention concerne des composés utiles en tant qu'inhibiteurs de protéine kinase ayant la formule (I) dans laquelle R?1¿, R?2¿, T et Ht ont la notation figurant dans la description. Les composés sont utiles pour traiter des états pathologiques chez des mammifères, lesquels sont soulagés par un inhibiteur de protéine kinase, en particulier des maladies telles que le cancer, les troubles inflammatoires, la resténose et des maladies cardio-vasculaires.

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