Pyrazole compositions useful as inhibitors of erk

Details Pyrazole compositions useful as inhibitors of erk Pyrazole compositions useful as inhibitors of erk

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/4155 (2006.01) A61L 27/28 (2006.01) A61L 31/08 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2369504

Described herein are compounds that are useful as protein kinase inhibitors having the formula: (I) where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

La présente invention concerne des composés utiles comme inhibiteurs de la protéine kinase représentés par la formule (I) dans laquelle R<1-4>, Q, et T sont décrits dans le descriptif. Ces composés sont utiles pour traiter certaines maladies chez les mammifères dont en atténue les symptômes en administrant un inhibiteur de protéine kinase, particulièrement pour des maladies telles que le cancer, les troubles inflammatoires, la resténose, et les maladies cardio-vasculaires.

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