Pyrazole compositions useful as inhibitors of gsk-3

Details Pyrazole compositions useful as inhibitors of gsk-3 Pyrazole compositions useful as inhibitors of gsk-3

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4155 (2006.01) A61K 31/4427 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2494100

The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

La présente invention concerne un composé représenté par la formule (I) ou un dérivé de ce composé répondant aux normes pharmaceutiques. Ces composés sont des inhibiteurs de protéine kinases, en particulier des inhibiteurs de protéine kinase humaines GSK3. Cette invention concerne aussi des compositions répondant aux normes pharmaceutiques comprenant les composés de l'invention et des techniques d'utilisation de ces composés et de ces compositions dans le traitement de diverses pathologies induites par protéine kinase.

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