C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/407 (2006.01) A61K 31/416 (2006.01) A61K 31/4162 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/4196 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/43 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/4985 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 21/00 (2006.01) A6
Patent
CA 2482838
A novel compound having excellent JNK inhibitory activity. It is a compound represented by the following general formula or a salt thereof. (I) In the formula, R1 represents -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb, and Rc each independently represents hydrogen, halogeno, hydroxy, optionally substituted C1-6 alkyl, etc.); Cy means a 5- or 6-membered aromatic heterocycle; and V's each independently means -L-X-Y ~wherein L means a single bond, optionally substituted C1-6 alkylene, etc.; X means a single bond, -A- (wherein A represents NR2, O, CO, S, SO, or SO2), etc.; and Y means hydrogen, halogeno, nitro, etc.~.
L'invention concerne un nouveau composé qui présente une excellente activité inhibitrice sur la JNK. Ce composé, ou son sel, est représenté par la formule générale (I). Dans cette formule, R?1¿ représente (CO)¿h?-(NR?a¿)¿j?-(CR?b¿=CR?c¿)¿k?-Ar (R?a¿, R?b¿ et R?c¿ représentant chacun hydrogène, halogène, hydroxy, C¿1-6? alkyle éventuellement substitué, etc.) ; Cy représente un hétérocycle aromatique à 5 ou 6 chaînons ; et les V représentent individuellement L-X-Y ÝL représentant une liaison simple , C¿1-6? alkylène éventuellement substitué, etc. ; X représentant une liaison simple, -A- (A représentant NR?2¿, O, CO, S, SO, ou SO¿2?, etc. ; et Y représente hydrogène, halogène, nitro, etc.¨.
Doko Takashi
Motoki Takafumi
Naoe Yoshimitsu
Ohi Norihito
Sato Nobuaki
Eisai Co. Ltd.
Eisai R&d Management Co. Ltd.
Smart & Biggar
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