Pyrazole compounds as anti-inflammatory and analgesic agents

Details Pyrazole compounds as anti-inflammatory and analgesic agents Pyrazole compounds as anti-inflammatory and analgesic agents

C - Chemistry, Metallurgy

07

D

C07D 231/12 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 231/14 (2006.01) C07D 231/16 (2006.01) C07D 231/38 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2482382

This invention provides a compound of the formula (I): wherein: R1 represents a hydrogen atom, an alkyl group, etc.; R2 represents a hydrogen atom, a halogen atom, etc.; R3 represents an alkyl group, etc.; R4 represents an aryl group, etc.; A represents an aryll, etc; B represents an alkylene etc.; X represents NH, etc.; or a pharmaceutically acceptable ester of such compound, and pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of medical conditions mediated by prostaglandin such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.

L'invention concerne un composé représenté par la formule (I), dans laquelle R?1¿ représente un atome d'hydrogène, un groupe alkyle, etc., R?2¿ représente un atome d'hydrogène, un atome d'halogène, etc., R?3¿ représente un groupe alkyle, etc., R?4¿ représente un groupe aryle, etc., A représente un aryle?l¿, etc., B représente un alcoylène, etc., X représente NH, etc., ou un ester pharmaceutiquement acceptable d'un tel composé et des sels pharmaceutiquement acceptables d'un tel composé. Ces composés sont utiles dans le traitement d'états médicaux à médiation assurée par la prostaglandine tels que douleur, fièvre ou inflammation, etc. Cette invention concerne également une composition pharmaceutique contenant le composé susmentionné.

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