Pyrazole compounds as ccr1 antagonists

Details Pyrazole compounds as ccr1 antagonists Pyrazole compounds as ccr1 antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/415 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) C07D 231/14 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2722811

Disclosed are compounds of the formula I which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

La présente invention concerne des composés de formule I qui bloquent linteraction de CCR1 et de ses ligands et qui sont donc utiles pour le traitement dune variété de maladies et pathologies qui sont médiées ou soutenues par lactivité de CCR1 parmi lesquelles les maladies auto-immunes, telles que la polyarthrite rhumatoïde et la sclérose en plaques. Linvention concerne également des compositions pharmaceutiques comprenant ces composés, des procédés dutilisation de ces composés dans le traitement de diverses maladies et pathologies, des procédés de préparation de ces composés et des intermédiaires utiles dans ces procédés.

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