Pyrazole compounds as integrin receptor antagonists derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2507958

The present invention relates to pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the .alpha.V.beta.3 and/or the .alpha. V.beta.5 integrin without significantly inhibiting the .alpha. V.beta.6 integrin.

La présente invention concerne des compositions pharmaceutiques qui renferment des composés de formule (I), et des méthodes permettant d'inhiber ou d'antagoniser sélectivement l'intégrine .alpha.¿V?.beta.¿3? et/ou l'intégrine .alpha.¿ V?.beta.¿5 ?sans inhiber considérablement l'intégrine .alpha.¿ V?.beta.¿6?.

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