C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/40 (2006.01) A61K 31/415 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2501799
The invention provides compounds of Formula (I): wherein R1,R2,R3, R4,R6,R7, R8 and A are as defined. Compounds of formula (I) have activity inhibiting production of A.beta.-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula (I).
La présente invention concerne des composés représentés par la formule générale (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?6¿, R?7¿, R?8¿ et A sont tels que défini. Ces composés représentés par la formule (I) agissent comme inhibiteurs de la production du peptide A.beta.. L'invention concerne également des compositions pharmaceutiques et des procédés destinés au traitement de maladies, notamment de la maladie d'Alzheimer, chez des mammifères, lesquelles compositions comprennent les composés représentés par la formule (I).
Allen Martin Patrick
Chen Yuhpyng L.
Liras Spiros
Rosati Robert L.
Pfizer Products Inc.
Smart & Biggar
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