C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01) C07D 407/14 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2593993
The invention provides a compound of the formula (I): or a salt, solvate, tautomer or N-oxide thereof, wherein M is selected from a group D1 and a group D2: and R', E, A and X are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, processes for making the compounds and the use of the compounds in the prophylaxis or treatment of a disease state mediated by a CDK kinase, GSK-3 kinase or Aurora kinase.
La présente invention concerne un composé de formule (I) : ou un sel, un solvate, un tautomère ou un N-oxyde dudit composé, dans lequel M est choisi parmi un groupe D1 et un groupe D2: et R', E, A et X sont tels que définis dans les revendications. La présente invention concerne également des compositions pharmaceutiques contenant les composés, des procédés pour la fabrication des composés et l~utilisation des composés dans la prophylaxie ou dans le traitement d~un état pathologique induit par une kinase CDK, une kinase GSK-3 ou une kinase Aurora.
Berdini Valerio
Carr Maria Grazia
Gill Adrian Liam
Howard Steven
Navarro Eva Figueroa
Astex Therapeutics Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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