Pyrazole compounds useful as protein kinase inhibitors

Details Pyrazole compounds useful as protein kinase inhibitors Pyrazole compounds useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2432872

This invention describes novel pyrazole compounds of formula (II ):wherein Z1 is nitrogen or CR8; Q is -S-, -O-, -N(R4)-, or -CH (R6)-; R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and Ry, R2, and R2' are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzeimer's disease.

L'invention concerne des nouveaux composés de pyrazole de formule II: dans laquelle Z?1¿ représente un azote ou CR?8¿; Q représente -S-, -O-, -N(R?4¿)-, ou -CH (R?6¿)-; R?1¿ représente un noyau D à liaison T, le noyau D désignant un noyau monocyclique à 5-7 chaînons ou un noyau bicyclique à 8-10 chaînons sélectionné parmi l'aryle, l'hétéroaryle, l'hétérocyclyle ou le carbocyclyle; et R?y¿, R?2¿ et R?2'¿ sont tels que définis dans la description. Les composés sont utiles comme inhibiteurs de protéines kinases, notamment comme inhibiteurs des protéines kinases Aurora-2 et GSK-3, aux fins de traitement de maladies telles que le cancer, les diabètes et la maladie d'Alzheimer.

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