Pyrazole compounds useful as protein kinase inhibitors

Details Pyrazole compounds useful as protein kinase inhibitors Pyrazole compounds useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4155 (2006.01) A61K 31/416 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 475/10 (2006.01) C07D 487/04 (2006.01) C07D 491/044 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2422379

This invention describes novel pyrazole compounds of formula II:wherein Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1, 2, 4-triazinyl ring, and R2, R2, Rx, and Ry are as described in the specification. Ring C has an ortho substituent and is optionally substituted in the non-ortho positions. R2 and R2 are optionally taken together with their intervening atoms to form a fused ring system, such as an indazole ring; and Rx and Ry are optionally taken together with their intervening atoms to form a fused ring system, such as a quinazoline ring. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3, for treating diseases such as diabetes and Alzheimer's disease.

L'invention concerne des composés pyrazole de formule II: dans laquelle le noyau C est choisi parmi un noyau phényle, pyridinyle, pyrimidinyle, pyridazinyle, pyrazinyle, ou un noyau 1, 2, 4-triazinyle, et dans laquelle R?2¿, R?2¿, R?x¿, et R?y¿ sont tels que mentionnés dans la description. Le noyau C comporte un substituant en ortho et il est éventuellement substitué sur les autres positions. R?2¿ et R?2¿ sont éventuellement pris ensemble avec leurs atomes intermédiaires afin de former un système de cycles fusionnés, tel qu'un noyau indazole, et R?x¿ et R?y¿ sont éventuellement pris ensemble avec leurs atomes intermédiaires afin de former un système de cycles fusionnés, tels qu'un noyau quinazoline. Ces composés sont utiles en tant qu'inhibiteurs de protéine kinase, spécialement en tant qu'inhibiteurs de GSK-3, pour le traitement de maladies telles que le diabète et la maladie d'Alzheimer.

Affiliated with

Also associated with

Rating

Pyrazole compounds useful as protein kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrazole compounds useful as protein kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazole compounds useful as protein kinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1942759