Pyrazole compounds useful as protein kinase inhibitors

Details Pyrazole compounds useful as protein kinase inhibitors Pyrazole compounds useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/517 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2432131

This invention describes novel pyrazole compounds of formula (IIa): wherein R1 is T-Ring D, wherein Ring D is 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2' are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

L'invention concerne de nouveaux composés de pyrazole de la formule (IIa) dans laquelle R?1¿ représente T-cycle D, où le cycle D représente un cycle monocyclique à 5-7 éléments ou cycle bicyclique à 8-10 éléments choisi entre aryle, hétéroaryle, hétérocyclyle ou carbocyclyle; et R?x¿ et R?y¿ sont pris ensemble avec leurs atomes interposés pour former un cycle fusionné, insaturé ou partiellement insaturé de 5-7 éléments comprotant 0-3 hétéroatomes; et R?2¿ ainsi que R?2'¿ sont tels que décrits dans la description. Les composés sont utiles en tant qu'inhibiteurs de protéine kinase, en particulier en tant qu'inhibiteurs d'Aurora-2 et de GSK-3, pour traiter des maladies telles que le cancer, le diabète et la maladie d'Alzheimer.

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