Pyrazole compounds useful as protein kinase inhibitors

Details Pyrazole compounds useful as protein kinase inhibitors Pyrazole compounds useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/501 (2006.01) A61K 31/53 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2432132

This invention describes novel pyrazole compounds of formula III: see above formula wherein Z1, Z2, and Z3 are described in the specification; Q is -S-, -O-, -N(R4)-, or CH(R6)-; is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl; and R2 and R2' are as in the specification. The compounds are used as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and glycogen synthase kinase-3 (GSK-3), for treating diseases such as cancer, diabetes and Alzheimer's disease.

L'invention concerne de nouveaux composés de pyrazole correspondant à la formule (III) dans laquelle: Z<1>, Z<2> et Z<3> correspondent à la définition donnée dans la description; Q représente -S-, -O-, -N(R<4>)- ou bien -CH(R<6>)-; R<1> représente T-noyau D, ce noyau D étant un noyau monocyclique à 5 ou 7 éléments ou un noyau bicyclique à 8 ou 10 éléments sélectionnés parmi aryle, hétéroaryle, hétérocyclyle ou carbocyclyle; et R<2> et R<2'> correspondent à la définition donnée dans la description. Ces composés sont utiles en tant qu'inhibiteurs de la protéine kinase, spécialement en tant qu'inhibiteurs d'Aurora-2 et de GSK-3, pour le traitement de maladies telles que le cancer, le diabète et la maladie d'Alzheimer. < >

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