Pyrazole cyclic amp-specific pde inhibitors

Details Pyrazole cyclic amp-specific pde inhibitors Pyrazole cyclic amp-specific pde inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 231/14 (2006.01)

Patent

CA 2395113

Pyrazole compounds (I) that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed (I) wherein Y is O or NOH; Z is O or NH; R1 - R4 are as claimed.

L'invention concerne des composés pyrazole (1) qui sont des inhibiteurs actifs et sélectifs de PDE4, ainsi que des méthodes de préparation de ces composés. L'invention concerne également l'utilisation de ces composés pour traiter des maladies inflammatoires et d'autres maladies impliquant des niveaux élevés de cytokine, ainsi que des troubles du système nerveux central (CNS). Ces composés sont représentés par la formule (I) dans laquelle Y représente O ou NOH; Z représente O ou NH; R1-R4 sont tels que décrits dans les spécifications.

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