C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/02 (2006.01) A61K 31/7056 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01) A61P 43/00 (2006.01) C07D 231/20 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2500873
A pyrazole derivative which exerts an excellent effect of inhibiting human 1,5- anhydroglucitol/fructose/mannose transporters and, therefore, is useful as a preventive, a progress inhibitor or a remedy for a disease caused by the over intake of at least one saccharide selected from among glucose, fructose and mannose or a disease caused by hyperglycemia (diabetic complication, diabetes, etc.), its pharmacologically acceptable salt, prodrugs thereof, a medicinal composition containing the same, its medicinal use and an intermediate in the production thereof.
L'invention concerne un dérivé de pyrazole qui a un excellent potentiel d'inhibition des transporteurs de 1,5-anhydroglucitol/fructose/mannose de type humain, et qui est donc utile comme substance prophylactique, inhibiteur d'évolution ou remède pour une maladie engendrée par l'absorption excessive d'au moins un saccharide pouvant être glucose, fructose ou mannose, ou bien pour une maladie engendrée par hyperglycémie (complication diabétique, diabète, etc.), y compris le sel pharmaceutiquement acceptable ou les promédicaments correspondants. L'invention concerne également une composition médicinale renfermant ce dérivé, son utilisation médicinale et un intermédiaire entrant dans sa production.
Fujikura Hideki
Isaji Masayuki
Kikuchi Norihiko
Tazawa Shigeki
Yamato Tokuhisa
Kirby Eades Gale Baker
Kissei Pharmaceutical Co. Ltd.
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