Pyrazole derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/06 (2006.01) A61K 31/415 (2006.01) C07D 207/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2501502

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4, n W, X and Y are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

La présente invention concerne des dérivés de pyrazole représentés par la formule (I) ou des sels, des solvates ou de dérivés de ces composés répondant aux normes pharmaceutiques. Dans cette formule R?1¿ à R?4¿, n, W, X et Y sont tels que définis dans les descriptions. Cette invention concerne aussi des processus de préparation de ces composés, des intermédiaires utilisés dans la préparation de compositions contenant ces composés et les utilisations de ces dérivés. Les composés de cette invention se lient à l'enzyme transcriptase inverse et sont des modulateurs et, plus particulièrement des inhibiteurs de celle-ci. En tant que tels, ces composés conviennent pour le traitement de diverses pathologies dans lesquelles l'inhibition de la transcriptase inverse est impliquée. Des pathologies d'intérêt incluent les pathologies induites par le virus de l'immunodéficence humaine VIH et par les virus génétiquement liés, telles que de syndrome d'immunodéficience acquis (SIDA).

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