Pyrazole derivatives

Details Pyrazole derivatives Pyrazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/395 (2006.01) A61K 31/675 (2006.01) C07D 231/38 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 453/02 (2006.01) C07D 473/00 (2006.01) C07D 475/00 (2006.01) C07F 9/547 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2158737

Pyrazole compounds of formula [1] and their tautomers and salts: Image [1] (wherein R1 is an alkyl group, etc.; R2 is a carboxyl group, etc.; R3 is a halogen atom, an alkyl group, a phenyl group, etc.; R4, R5 and R6 each are a hydrogen atom, a halogen atom, etc.; R7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.). The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.

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