Pyrazole derivatives as anti-inflammatory/analgesic agents

Details Pyrazole derivatives as anti-inflammatory/analgesic agents Pyrazole derivatives as anti-inflammatory/analgesic agents

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07D 231/54 (2006.01) C07D 491/04 (2006.01) C07D 491/052 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2343459

Disclosed are compounds of the formula: (see formula I) (wherein n is 0-4; p is 1 or 2; X is CR7 or N; Y is CR8 or N; Z is CHR9, O, S, SO, SO2 or NR10; W is CR5R6; R1 is CF3 or CHF2; R2 is alkyl; R3 is H or substituent; R4 is H or substituent; and R5, R6, R7, R8, R9 and R10 are H, alkyl or the like). The compounds are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats, horses and livestock.

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