Pyrazole derivatives as phosphodiesterase 4 inhibitors

Details Pyrazole derivatives as phosphodiesterase 4 inhibitors Pyrazole derivatives as phosphodiesterase 4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/4155 (2006.01) A61K 31/416 (2006.01) A61P 25/00 (2006.01) C07D 231/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2522687

Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

L'invention porte sur des composés aryle et hétéroaryle de pyrazole inhibiteurs sélectifs de la PDE4 dont l'activité inhibitrice est améliorée par rapport à des composés tels que le rolipram et qui présentent une sélectivité quant à l'inhibition des autres classes de PDEs.

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