Pyrazole derivatives as phosphodiesterase 4 inhibitors

Details Pyrazole derivatives as phosphodiesterase 4 inhibitors Pyrazole derivatives as phosphodiesterase 4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 407/12 (2006.01) A61K 31/4155 (2006.01) A61P 25/00 (2006.01) C07D 231/12 (2006.01) C07D 403/04 (2006.01) C07D 407/04 (2006.01)

Patent

CA 2584317

Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

L'inhibition sélective de PDE4 est effectuée au moyen de composés d'aryle et d'hétéroaryle pyrazole. Ces composés présentent une inhibition améliorée de PDE4 en comparaison avec des composés tels que rolipram et possèdent une certaine sélectivité par rapport à l'inhibition d'autres classes de PDE.

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