Pyrazole derivatives for the treatment of viral diseases

Details Pyrazole derivatives for the treatment of viral diseases Pyrazole derivatives for the treatment of viral diseases

C - Chemistry, Metallurgy

07

D

C07D 231/18 (2006.01) A61K 31/415 (2006.01) A61K 31/422 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 31/18 (2006.01) C07D 401/02 (2006.01) C07D 403/02 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2423515

The invention is concerned with novel and known pyrazole derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula (I) are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HIV mediated process. Specifically the invention describes the use of compounds of formula (I) for the treatment of diseases mediated by the human immunodeficiency virus (HIV) or for the preparation of a medicament for such treatment.

L'invention concerne des dérivés pyrazole nouveaux et connus, un procédé destiné à leur fabrication, des compositions pharmaceutiques et l'utilisation de ces composants en médecine. Les composés de formule (I), de l'invention, sont des inhibiteurs de l'enzyme de transcriptase inverse du virus d'immunodéficience humaine qui est impliqué dans la réplication virale. Par conséquent, ces composés peuvent être utilisés de manière avantageuse en tant qu'agents thérapeutiques dans un procédé induit par le VIH. Cette invention décrit notamment l'utilisation de composés de formule (I) destinés au traitement de maladies induites par le virus de l'immunodéficience humaine (VIH) ou à la préparation d'un médicament destiné à un tel traitement.

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