C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/18 (2006.01) A61K 31/415 (2006.01) A61P 31/18 (2006.01) A61K 31/4155 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2443449
This invention relates to pyrazole derivatives of the formula, or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implacated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Aquired Immune Deficiency Syndrome (AIDS).
La présente invention a trait à de dérivés de pyrazole de formule (I), dans laquelle R1 à R4 sont tels que définis dans la description ou leurs sels, solvates ou des dérivés de ceux-ci pharmaceutiquement acceptables, ainsi que leurs procédés de préparation, des intermédiaires utilisés dans leur préparation, des compositions les contenant et les utilisations de tels dérivés. Les composés de la présente invention se lient à l'enzyme de la transcriptase inverse et sont des modulateurs, notamment des inhibiteurs de celle-ci. En tant que tels les composés de l'invention sont utiles dans le traitement d'une variété de troubles y compris ceux dans lesquels l'inhibition de la transcriptase inverse est impliquée. Les troubles concernés comprennent ceux provoqués par le virus de l'immunodéficience humaine (VIH) et les rétrovirus associés, tels que le syndrome d'immunodéficience acquis (SIDA).
Jones Lyn Howard
Mowbray Charles Eric
Price David Anthony
Selby Matthew Duncan
Stupple Paul Anthony
Pfizer Inc.
Smart & Biggar
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