Pyrazole derivatives useful as inhibitors of faah

Details Pyrazole derivatives useful as inhibitors of faah Pyrazole derivatives useful as inhibitors of faah

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/415 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 231/18 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 409/14 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2727242

The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as ac-tive ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease

La présente invention concerne certains dérivés d'imidazole qui sont utiles comme inhibiteurs d'amide hydrolase des acides gras (FAAH). L'invention concerne également des formulations pharmaceutiques comprenant ces composés comme ingrédients actifs et l'utilisation des composés et de leurs formulations dans le traitement de certaines affections, notamment l'arthrose, la polyarthrite rhumatoïde, la néphropathie diabétique, l'algie post-zona, la douleur squeletto-musculaire, la fibromyalgie, ainsi que la douleur aiguë, la migraine, les troubles du sommeil, la maladie d'Alzheimer, et la maladie de Parkinson.

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