Pyrazole derivatives with an ergoline skeleton, their acid...

Details Pyrazole derivatives with an ergoline skeleton, their acid... Pyrazole derivatives with an ergoline skeleton, their acid...

C - Chemistry, Metallurgy

07

D

167/227, 260/206

C07D 457/02 (2006.01) A61K 31/48 (2006.01)

Patent

CA 1252086

ABSTRACT The invention relates to novel pyrazole deriva- tives with an ergoline skeleton of the general formula I, Image wherein x...y stands for a -CH=C- or -CH2-CH- group, I ! R is a hydrogen atom or methyl group, R1 stands for a hydrogen atom, C1 4 alkyl, carb- ethoxy or pyridyl-group, R2 stands for a hyclrogen atom, C1 4 alkyl, allyl, -2- C2-4 oxoalkyl-, C2-4 hydroxyalkyl or C2-4 hydroxyiminoalkyl group, R3 stands for a hydrogen atom, C1-4 alkyl, hydroxy or pyridyl group, furthermore R2 and R3 may stand together for a group of general formula ( II) , Image II wherein Z stands for a methylene, carbonyl, hydroxy- methylene or hydroxyiminomethylene group, R4 stands for a hydrogen atom or one or two C1-4 alkyl group(s), and n is 1 or 2, and pharmaceutically acceptable salts thereof Furthermore the invention relates to a process for the preparation of these compounds The novel compounds are potent PGF2? receptor antagonists.

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