Pyrazole-derived kinase inhibitors and uses thereof

Details Pyrazole-derived kinase inhibitors and uses thereof Pyrazole-derived kinase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4155 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2456187

Described herein are compounds that are useful as protein kinase inhibitors having the formula: (1) , where B, Rl, n, R3, Q, and R4 are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

L'invention concerne des composés utilisés en tant qu'inhibiteurs de protéine kinase de formule : (1) ; B, R?1¿, n, R?3¿, Q, et R?4¿ étant spécifiés dans le descriptif. Lesdits composés sont utiles dans le traitement des états pathologiques, chez les mammifères, qui sont atténués par des inhibiteurs de protéine kinase, en particulier des maladies telles que le cancer, les troubles inflammatoires, la resténose, et les maladies cardio-vasculaires.

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