Pyrazole-derived kinase inhibitors and uses thereof

Details Pyrazole-derived kinase inhibitors and uses thereof Pyrazole-derived kinase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/4155 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2456192

Described herein are compounds that are useful as protein kinase inhibitors having the formula (I) wherein B, R1, n, R3, Q and R4 are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

L'invention concerne des composés utilisés comme inhibiteurs de la protéine kinase de formule (I) dans laquelle B, R?1¿, n, R?3¿, Q et R?4¿ ont la signification indiquée dans le descriptif. Lesdits composés sont utiles dans le traitement de maladies, chez les mammifères, qui sont atténuées par un inhibiteur de la protéine kinase, en particulier des maladies telles que le cancer, les troubles inflammatoires, la resténose et les maladies cardio-vasculaires.

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