A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/496 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/4439 (2006.01)
Patent
CA 2579313
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferationm, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/0r modulate kinases. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase- dependent diseases and conditions are also an aspect of the invention.
La présente invention se rapporte à des composés destinés à moduler l'activité enzymatique des protéines kinases afin de moduler des activités cellulaires telles que la prolifération, la différenciation, la mort cellulaire programmée, la migration et la chimio-invasion. Les composés selon l'invention inhibent, régulent et/ou modulent les kinases. Dans un aspect, l'invention a également trait à des procédés d'utilisation des composés et de compositions pharmaceutiques à base de ces derniers pour traiter des maladies et des troubles liés aux kinases.
Baik Tae-Gon
Buhr Chris A.
Ma Sunghoon
Nuss John M.
Tesfai Zerom
Bennett Jones Llp
Exelixis Inc.
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