Pyrazole-substituted aminoheteroaryl compounds as protein...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2577937

Compounds of formula (1) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

La présente invention concerne des composés de formule (1), ainsi que des procédés pour les synthétiser et les utiliser. Les composés préférés sont des inhibiteurs puissants de la protéine kinase c-Met et sont utilisés pour traiter des troubles de croissance cellulaire anormale, par exemple des cancers.

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