Pyrazoles

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C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/415 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01) A61P 27/06 (2006.01) A61P 35/00 (2006.01) C07D 231/52 (2006.01) C07D 239/52 (2006.01) C07D 239/69 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2315614

Compounds of formulae (IA) and (IB): Image wherein R1, R2, R3, Ar1 and X are as defined in the specification, are endothelin antagonists. The compounds are therefore useful in the treatment of a variety of conditions mediated by endothelin, such as restenosis, renal failure and systemic and pulmonary hypertension.

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