Pyrazoles and pyrazolopyrimidines

Details Pyrazoles and pyrazolopyrimidines Pyrazoles and pyrazolopyrimidines

C - Chemistry, Metallurgy

07

D

C07D 231/14 (2006.01) A61K 31/395 (2006.01) C07D 231/18 (2006.01) C07D 231/38 (2006.01) C07D 231/44 (2006.01) C07D 231/52 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 403/10 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 409/10 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2150483

The pyrazoles and pyrazolopyrimidines of formula (I) wherein R1, R2, R3. R4 and A are as defined herein, have corticotropin releasing factor (CRF) antagonist activity. As such, they are effective in the treatment of a wide range of diseases including stress-related illnesses.

L'invention concerne des pyrazoles et des pyrazolopyrimidines représentés par la formule (I) dans laquelle R1, R2, R3, R4 et A sont définis dans le dossier. Ces derniers qui présentent une activité antagnoiste du facteur de libération de la cortitrophine sont efficaces dans le traitement d'un grand nombre de maladies dont les affections liées au stress.

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