Pyrazoles as glucokinase activators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 231/40 (2006.01) A61K 31/25 (2006.01) A61K 31/341 (2006.01) A61K 31/415 (2006.01) A61K 31/5377 (2006.01) A61P 1/18 (2006.01) C07D 405/12 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2657566

Disclosed herein are pyrazole glucokinase activators of the formula (I) wherein R1 to R4 are as defined in the specification and claims, useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.

L'invention concerne des activateurs de glucokinase de type pyrazole de la formule (I), dans laquelle R1 à R4 sont tels que définis dans la description et les revendications, utiles pour le traitement de maladies métaboliques et de troubles, de préférence le diabète.

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